The lethal dose of Marplan in humans is not known. To avoid potentiation, the physician wishing to terminate treatment with Marplan and begin therapy with another agent should allow for an interval of 10 days. The monoamine oxidase inhibitory effects of Marplan may persist for a substantial period after discontinuation of the drug, and this should be borne in mind when another drug is prescribed following Marplan. If combination therapy is needed, careful consideration should be given to the pharmacology of all agents to be used. This is especially true in patients who may subject themselves to an overdosage of drugs.
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In a single study, rats given high intraperitoneal doses of an MAO inhibitor plus disulfiram experienced severe toxicity, including convulsions and death.Ĭoncomitant use of Marplan and other psychotropic agents is generally not recommended because of possible potentiating effects. Marplan should be administered with caution to patients receiving Antabuse® (disulfiram, Wyeth-Ayerst Laboratories). See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS sections for information on drug interactions. News in Media Published Studies Curr't Clinical Trials Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Active Ingredients Marplan (Isocarboxazid) - Drug Interactions, Contraindications, Overdosage, etc Rx drug information, pharmaceutical research, clinical trials, news, and more Marplan (Isocarboxazid) - Drug Interactions, Contraindications, Other Rx Info